The number of major employers – not merely companies but also government entities – now requiring workers to be vaccinated is skyrocketing following the Food and Drug Administration’s approval of the Pfizer coronavirus vaccine. This means the door is closing on holdouts who have ignored science and stubbornly refused to get vaccinated. They now face a stark choice: relent or face big hassles and potential unemployment.

The tide has turned. Responsible Americans who stepped up and got the jab, believing that this was their ticket to pre-pandemic normalcy, have been held hostage by vaccine refuseniks. The latter group’s susceptibility to coronavirus infection is causing new infection rates to soar again, clogging hospital intensive care units and overwhelming health care resources.

A version of this editorial first appeared in the St. Louis Post-Dispatch.